| http://purl.uniprot.org/citations/15748999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15748999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15748999 | http://www.w3.org/2000/01/rdf-schema#comment | "Thrombospondins-1 and -2 (TSP-1, TSP-2) are matricellular glycoproteins with potent antiangiogenic activity. We have previously shown that the antiangiogenic activity of TSP-1 is mediated by the interaction of the type I repeats (TSR) with the receptor CD36, although other domains of TSP-1 have also been implicated. We now show that the antiangiogenic activity of TSP-2, which contains three TSRs but, unlike TSP-1, lacks the capacity to activate TGF-beta, is similarly dependent on CD36. Using the corneal pocket assay we found that TSP-2 did not inhibit bFGF-induced angiogenesis in CD36 null mice. We then demonstrated that (125)[I]-TSP-2 bound to murine macrophages and that binding was diminished by 70% by anti-CD36 antibody or by using cells from CD36 null animals. Solid-phase binding studies revealed that (125)[I]-TSP-2 bound to CD36/glutathione-S-transferase (GST) fusion proteins encoding the region spanning amino acids 93-120, but not amino acids 298-439. This 93-120 amino acid region, previously identified as the TSP-1 binding site, is homologous to domains on other TSP binding proteins, such as LIMP-2 and histidine-rich glycoprotein (HRGP). Finally, we showed with an immunoabsorbent binding assay that TSP-2 bound HRGP with high affinity and that HRGP blocked the antiangiogenic activity of TSP-2, acting like a "decoy" receptor. These data suggest that modulation of the TSR/CD36 system may play an important role in the regulation of the angiogenic "switch," and may provide a target for therapeutic interventions."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2004.11.005"xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2004.11.005"xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/author | "Febbraio M."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/author | "Febbraio M."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/author | "Silverstein R.L."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/author | "Silverstein R.L."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/author | "Simantov R."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/author | "Simantov R."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/name | "Matrix Biol."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/name | "Matrix Biol."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/pages | "27-34"xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/pages | "27-34"xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/title | "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/title | "The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15748999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15748999 |
| http://purl.uniprot.org/citations/15748999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15748999 |
| http://purl.uniprot.org/citations/15748999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15748999 |
| http://purl.uniprot.org/citations/15748999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15748999 |