| http://purl.uniprot.org/citations/15753378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15753378 | http://www.w3.org/2000/01/rdf-schema#comment | "The inducible form of cyclooxygenase (COX), COX-2, is up-regulated in many epithelial cancers and its prostaglandin products increase proliferation, enhance angiogenesis, and inhibit apoptosis in several tissues. Pharmacologic inhibition and genetic deletion studies showed a marked reduction of tumor development in colon and skin. COX-2 has also been strongly implicated in urinary bladder cancer primarily by studies with nonselective COX- and COX-2-selective inhibitors. We now show that forced expression of COX-2, under the control of a keratin 5 promoter, is sufficient to cause transitional cell hyperplasia (TCH) in 17% and 75% of the heterozygous and homozygous transgenic lines, respectively, in an age-dependent manner. TCH was strongly associated with inflammation, primarily nodules of B lymphocytes; some T cells and macrophage infiltration were also observed. Additionally, transitional cell carcinoma was observed in approximately 10% of the K5.COX-2 transgenic mice; no TCH or transitional cell carcinoma was observed in wild-type bladders. Immunohistochemistry for vascular proliferation and vascular endothelial growth factor showed significant increases above that in wild-type urinary bladders. Our results suggest that overexpression of COX-2 is sufficient to cause hyperplasia and carcinomas in the urinary bladder. Therefore, inhibition of COX-2 should continue to be pursued as a potential chemopreventive and therapeutic strategy."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-04-3567"xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Fischer S.M."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Klein R.D."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Furstenberger G."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Van Pelt C.S."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Muller-Decker K."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Sabichi A.L."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/author | "Dela Cerda J."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/pages | "1808-1813"xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/title | "Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression."xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://purl.uniprot.org/core/volume | "65"xsd:string |
| http://purl.uniprot.org/citations/15753378 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15753378 |
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