| http://purl.uniprot.org/citations/15755723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15755723 | http://www.w3.org/2000/01/rdf-schema#comment | "Lysophosphatidic acid (LPA) is a serum-derived phospholipid that induces a variety of biological responses in various cells via heterotrimeric G protein-coupled receptors (GPCRs) including LPA1, LPA2, and LPA3. LPA-induced cytoskeletal changes are mediated by Rho family small GTPases, such as RhoA, Rac1, and Cdc42. One of these small GTPases, RhoA, may be activated via Galpha(12/13)-linked Rho-specific guanine nucleotide exchange factors (RhoGEFs) under LPA stimulation although the detailed mechanisms are poorly understood. Here, we show that the C terminus of LPA1 and LPA2 but not LPA3 interact with the PDZ domains of PDZ domain-containing RhoGEFs, PDZ-RhoGEF, and LARG, which are comprised of PDZ, RGS, Dbl homology (DH), and pleckstrin homology (PH) domains. In LPA1- and LPA2-transfected HEK293 cells, LPA-induced RhoA activation was observed although the C terminus of LPA1 and LPA2 mutants, which failed to interact with the PDZ domains, did not cause LPA-induced RhoA activation. Furthermore, overexpression of the PDZ domains of PDZ domain-containing RhoGEFs served as dominant negative mutants for LPA-induced RhoA activation. Taken together, these results indicate that formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation."xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m414561200"xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/author | "Inagaki S."xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/author | "Kogo M."xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/author | "Ohoka Y."xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/pages | "19358-19363"xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/title | "Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)."xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15755723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15755723 |
| http://purl.uniprot.org/citations/15755723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15755723 |
| http://purl.uniprot.org/uniprot/O15085#attribution-D6B6859BF01B0674D2474AE4C6AE7825 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15755723 |
| http://purl.uniprot.org/uniprot/Q9NZN5#attribution-D6B6859BF01B0674D2474AE4C6AE7825 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15755723 |
| http://purl.uniprot.org/uniprot/P61793#attribution-5C0AEB99CF779D50F2AE5E10A7EF50D9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15755723 |
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