| http://purl.uniprot.org/citations/15764709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15764709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15764709 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal transducer and activator of transcription 3 (STAT3) is activated by the IL-6 family of cytokines and growth factors. STAT3 requires phosphorylation on Ser-727, in addition to tyrosine phosphorylation on Tyr-705, to be transcriptionally active. In IL-6 signaling, the two major pathways that derive from the YXXQ and the YSTV motifs of gp130 cause Ser-727 phosphorylation. Here, we show that TGF-beta-activated kinase 1 (TAK1) interacts with STAT3, that the TAK1-Nemo-like kinase (NLK) pathway is efficiently activated by IL-6 through the YXXQ motif, and that this is the YXXQ-mediated H7-sensitive pathway that leads to STAT3 Ser-727 phosphorylation. Because NLK was recently shown to interact with STAT3, we explored the role of STAT3 in activating this pathway. Depletion of STAT3 diminished the IL-6-induced NLK activation by >80% without inhibiting IL-6-induced TAK1 activation or its nuclear entry. We found that STAT3 functioned as a scaffold for TAK1 and NLK in vivo through a region in its carboxyl terminus. Furthermore, the expression of the STAT3(534-770) region in the nuclei of STAT3-knockdown cells enhanced the IL-6-induced NLK activation in a dose-dependent manner but not the TGFbeta-induced NLK activation. TGFbeta did not cause STAT3 Ser-727 phosphorylation, even when the carboxyl region of STAT3 was expressed in the nuclei. Together, these results indicate that STAT3 enhances the efficiency of its own Ser-727 phosphorylation by acting as a scaffold for the TAK1-NLK kinases, specifically in the YXXQ motif-derived pathway."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500679102"xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500679102"xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Kojima H."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Kojima H."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Iemura S."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Iemura S."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Sasaki T."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Sasaki T."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Kaneko S."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Kaneko S."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Nakajima K."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Nakajima K."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Kunimoto H."xsd:string |
| http://purl.uniprot.org/citations/15764709 | http://purl.uniprot.org/core/author | "Kunimoto H."xsd:string |