| http://purl.uniprot.org/citations/15766527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15766527 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal differentiation in C. elegans. Here we show that the let-7 family negatively regulates let-60/RAS. Loss of let-60/RAS suppresses let-7, and the let-60/RAS 3'UTR contains multiple let-7 complementary sites (LCSs), restricting reporter gene expression in a let-7-dependent manner. mir-84, a let-7 family member, is largely absent in vulval precursor cell P6.p at the time that let-60/RAS specifies the 1 degrees vulval fate in that cell, and mir-84 overexpression suppresses the multivulva phenotype of activating let-60/RAS mutations. The 3'UTRs of the human RAS genes contain multiple LCSs, allowing let-7 to regulate RAS expression. let-7 expression is lower in lung tumors than in normal lung tissue, while RAS protein is significantly higher in lung tumors, providing a possible mechanism for let-7 in cancer."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.01.014"xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Brown D."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Cheng A."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Slack F.J."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Johnson S.M."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Grosshans H."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Jarvis R."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Reinert K.L."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Labourier E."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Byrom M."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/author | "Shingara J."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/pages | "635-647"xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/title | "RAS is regulated by the let-7 microRNA family."xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/15766527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15766527 |
| http://purl.uniprot.org/citations/15766527 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15766527 |
| http://purl.uniprot.org/uniprot/#_P22981-mappedCitation-15766527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15766527 |
| http://purl.uniprot.org/uniprot/P22981 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15766527 |