| http://purl.uniprot.org/citations/15767370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767370 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-alpha in plasmacytoid dendritic cells (pDCs). This induction requires the formation of a complex consisting of the adaptor MyD88, tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and IFN regulatory factor (IRF) 7. Here we show an essential role of IL-1 receptor-associated kinase (IRAK)-1 in TLR7- and TLR9-mediated IRF7 signaling pathway. IRAK-1 directly bound and phosphorylated IRF7 in vitro. The kinase activity of IRAK-1 was necessary for transcriptional activation of IRF7. TLR7- and TLR9-mediated IFN-alpha production was abolished in Irak-1-deficient mice, whereas inflammatory cytokine production was not impaired. Despite normal activation of NF-kappaB and mitogen-activated protein kinases, IRF7 was not activated by a TLR9 ligand in Irak-1-deficient pDCs. These results indicated that IRAK-1 is a specific regulator for TLR7- and TLR9-mediated IFN-alpha induction in pDCs."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042372"xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042372"xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Takeshita F."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Takeshita F."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/15767370 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |