| http://purl.uniprot.org/citations/15767445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767445 | http://www.w3.org/2000/01/rdf-schema#comment | "Mumps virus (MuV) has been shown to antagonize the antiviral effects of interferon (IFN) through proteasome-mediated complete degradation of STAT1 by using the viral V protein (T. Kubota et al., Biochem. Biophys. Res. Commun. 283:255-259, 2001). However, we found that MuV could inhibit IFN signaling and the generation of a subsequent antiviral state long before the complete degradation of cellular STAT1 in infected cells. In MuV-infected cells, nuclear translocation and phosphorylation of STAT1 and STAT2 tyrosine residue (Y) at 701 and 689, respectively, by IFN-beta were significantly inhibited but the phosphorylation of Jak1 and Tyk2 was not inhibited. The transiently expressed MuV V protein also inhibited IFN-beta-induced Y701-STAT1 and Y689-STAT2 phosphorylation, suggesting that the V protein could block IFN-beta-induced signal transduction without the aid of other viral components. Finally, a substitution of an alanine residue in place of a cysteine residue in the C-terminal V-unique region known to be required for STAT1 degradation and inhibition of anti-IFN signaling resulted in the loss of V protein function to inhibit the Y701-STAT1 and Y689-STAT2 phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.7.4451-4459.2005"xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.7.4451-4459.2005"xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Fujii N."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Fujii N."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Yokosawa N."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Yokosawa N."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Tashiro M."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Tashiro M."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Yokota S."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/author | "Yokota S."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/pages | "4451-4459"xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/pages | "4451-4459"xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/title | "Mumps virus V protein antagonizes interferon without the complete degradation of STAT1."xsd:string |
| http://purl.uniprot.org/citations/15767445 | http://purl.uniprot.org/core/title | "Mumps virus V protein antagonizes interferon without the complete degradation of STAT1."xsd:string |