| http://purl.uniprot.org/citations/15767664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767664 | http://www.w3.org/2000/01/rdf-schema#comment | "Homeodomain transcription factors control a variety of essential cell fate decisions during development. To understand the developmental regulation by these transcription factors, we describe here the molecular analysis of paired-like CVC homeodomain protein (PLC-HDP) trafficking. Complementary experimental approaches demonstrated that PLC-HDP family members are exported by the Crm1 pathway and contain an evolutionary conserved leucine-rich nuclear export signal. Importantly, inactivation of the nuclear export signal enhanced protein stability, resulting in increased transactivation of transfected reporters and decreased extracellular secretion. In addition, PLC-HDPs harbor a conserved active nuclear import signal that could also function as a protein transduction domain. In our study, we characterized PLC-HDPs as mobile nucleocytoplasmic shuttle proteins with the potential for unconventional secretion and intercellular transfer. Nucleocytoplasmic transport may thus represent a conserved control mechanism to fine-tune the transcriptional activity of PLC-HDPs prerequisite for regulating and maintaining the complex expression pattern during development."xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.7.2573-2582.2005"xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/author | "Knauer S.K."xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/author | "Stauber R.H."xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/author | "Carra G."xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/pages | "2573-2582"xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/title | "Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion."xsd:string |
| http://purl.uniprot.org/citations/15767664 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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