| http://purl.uniprot.org/citations/15768032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15768032 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt growth factors mediate cell fate determination during embryogenesis and in the renewal of tissues in the adult. Wnts act by stabilizing cellular levels of the transcriptional coactivator beta-catenin, which forms complexes with sequence-specific DNA-binding Tcf/Lef transcription factors. In the absence of nuclear beta-catenin, Tcf/Lefs act as transcriptional repressors by binding to Groucho/TLE proteins. The molecular basis of the switch from transcriptional repression to activation during Wnt signaling has not been clear, in particular whether factors other than beta-catenin are required to disrupt the interaction between Groucho/TLE and Tcf/Lef. Using highly purified proteins, we demonstrate that beta-catenin displaces Groucho/TLE from Tcf/Lef by binding to a previously unidentified second, low-affinity binding site on Lef-1 that includes sequences just N-terminal to the DNA-binding domain, and that overlaps the Groucho/TLE-binding site."xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb912"xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/author | "Daniels D.L."xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/author | "Weis W.I."xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/pages | "364-371"xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/title | "Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation."xsd:string |
| http://purl.uniprot.org/citations/15768032 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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