| http://purl.uniprot.org/citations/15769735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15769735 | http://www.w3.org/2000/01/rdf-schema#comment | "The initiation of UV light-induced signaling in mammalian cells is largely considered to be subsequent to DNA damage. Several studies have also described ceramide (CER), a lipid second messenger, as a major contributor in mediating UV light-induced c-Jun N-terminal kinase (JNK) activation and cell death. It is demonstrated here that UV-C light irradiation of U937 cells results in the activation and translocation of a Zn2+-independent acid sphingomyelinase, leading to CER accumulation in raft microdomains. These CER-enriched rafts aggregate and play a functional role in JNK activation. The observation that UV-C light also induced CER generation and the externalization of acid sphingomyelinase and JNK in human platelets conclusively rules out the involvement of a nuclear signal generated by DNA damage in the initiation of a UV light response, which is generated at the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m412867200"xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/author | "Muller S."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/author | "Laurent G."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/author | "Jaffrezou J.P."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/author | "Grazide S."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/author | "Bezombes C."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/author | "Charruyer A."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/pages | "19196-19204"xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/title | "UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal."xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15769735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15769735 |
| http://purl.uniprot.org/citations/15769735 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15769735 |
| http://purl.uniprot.org/uniprot/#_Q15496-mappedCitation-15769735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15769735 |
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| http://purl.uniprot.org/uniprot/#_Q59EN6-mappedCitation-15769735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15769735 |
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