| http://purl.uniprot.org/citations/15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15772083 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of androgen receptor (AR) decreases estrogen receptor alpha (ERalpha) transactivation, which plays a basic role in hormone-dependent breast cancer. This transcriptional interference can be due to shared coactivators. Here we demonstrated that in MCF-7 cells ARA70, an AR-specific coactivator, interacted with endogenous ERalpha, increasing its transcriptional activity, and it was recruited to the pS2 gene promoter. Moreover, a dominant negative ARA70 down-regulated ERalpha transcriptional activity as well as pS2 mRNA. ARA70 overexpression reversed the AR down-regulatory effect on ERalpha signaling. However, in the presence of a progressive increase of transfected AR, ARA70 switched into enhancing the inhibitory effect of AR on ERalpha signaling. These opposite effects of ARA70 were further evidenced by coimmunoprecipitation assay in MCF-7wt, MCF-7-overexpressing AR, and HeLa cells, exogenously expressing an excess of ERalpha with respect to AR or an excess of AR with respect to ERalpha. Thus, ARA70 is a coactivator for ERalpha and may represent a functional link between ERalpha/AR modulating their cross-talk in models of estrogen signaling in MCF-7 and HeLa cells."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m413576200"xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/author | "Ando S."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/author | "Marsico S."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/author | "McPhaul M.J."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/author | "De Amicis F."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/author | "Lanzino M."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/author | "Panno M.L."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/pages | "20421-20430"xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/title | "Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells."xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15772083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15772083 |
| http://purl.uniprot.org/citations/15772083 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A087WUX9-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_D2KF13-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW2-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW3-mappedCitation-15772083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772083 |