| http://purl.uniprot.org/citations/15772169 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15772169 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15772169 | http://www.w3.org/2000/01/rdf-schema#comment | "Anthrax caused by Bacillus anthracis represents a major bioterroristic threat. B. anthracis produces lethal toxin (LeTx), a combination of lethal factor (LF) and protective antigen that plays a major role in anthrax pathogenesis. We demonstrate that human neutrophil alpha-defensins are potent inhibitors of LF. The inhibition of LF by human neutrophil protein (HNP-1) was noncompetitive. HNP-1 inhibited cleavage of a mitogen-activated protein kinase kinase and restored impaired mitogen-activated protein kinase signaling in LeTx-treated macrophages. HNP-1 rescued murine macrophages from B. anthracis-induced cytotoxicity, and in vivo treatment with HNP-1-3 protected mice against the fatal consequences of LeTx."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500508102"xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500508102"xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Fischer G."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Fischer G."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Wilmanns M."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Wilmanns M."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Kaufmann S.H."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Kaufmann S.H."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Song Y.H."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Song Y.H."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Hurwitz R."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Hurwitz R."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Gajendran N."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Gajendran N."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Mittruecker H.W."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Mittruecker H.W."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Weiwad M."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/author | "Weiwad M."xsd:string |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15772169 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |