| http://purl.uniprot.org/citations/15772250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15772250 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclosporine (CsA) nephrotoxicity is a severe complication in organ transplantation because it leads to impaired renal function and chronic allograft nephropathy, which is a major predictor of graft loss. Animal models and in vivo studies indicate that the transmembrane efflux pump P-glycoprotein contributes substantially to CsA nephrotoxicity. It was hypothesized that the TT genotype at the ABCB1 3435C-->T polymorphism, which is associated with decreased expression of P-glycoprotein in renal tissue, is a risk factor for developing CsA nephrotoxicity. In a case-control study, 18 of 97 patients developed CsA nephrotoxicity and showed complete recovery of renal function in all cases when switched to a calcineurin inhibitor-free regimen. Both recipients and donors were genotyped for ABCB1 polymorphisms at the positions 3435C-->T and 2677G-->T/A. For controlling for population stratification, two additional polymorphisms, CYP2D6*4 and CYP3A5*3, with intermediate allelic frequencies were studied. The P-glycoprotein low expressor genotype 3435TT only of renal organ donors but not of the recipients was overrepresented in patients with CsA nephrotoxicity as compared with patients without toxicity (chi2 = 10.5; P = 0.005). CsA dosage, trough levels, and the concentration per dose ratio were not different between the patient groups. In a multivariate model that included several other nongenetic covariates, only the donor's ABCB1 3435TT genotype was strongly associated with CsA nephrotoxicity (odds ratio, 13.4; 95% confidence interval, 1.2 to 148; P = 0.034). A dominant role of the donor's ABCB1 genotype was identified for development of CsA nephrotoxicity. This suggests that P-glycoprotein is an important factor in CsA nephrotoxicity."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2004100882"xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Geiger H."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Eichelbaum M."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Schaeffeler E."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Zanger U.M."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Schwab M."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Wegner B."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Seidl C."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Hauser I.A."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Hocher B."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Ackermann H."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Gauer S."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Gossmann J."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/author | "Scheuermann E.H."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/pages | "1501-1511"xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/title | "ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation."xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/15772250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15772250 |
| http://purl.uniprot.org/citations/15772250 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15772250 |
| http://purl.uniprot.org/uniprot/#_F4ZUY5-mappedCitation-15772250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772250 |
| http://purl.uniprot.org/uniprot/#_A1L471-mappedCitation-15772250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15772250 |