| http://purl.uniprot.org/citations/15772425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15772425 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung surfactant dipalmitoylphosphatidylcholine (DPPC) is endocytosed by alveolar epithelial cells and degraded by lysosomal-type phospholipase A2 (aiPLA2). This enzyme is identical to peroxiredoxin 6 (Prdx6), a bifunctional protein with PLA2 and GSH peroxidase activities. Lung phospholipid was studied in Prdx6 knockout (Prdx6-/-) mice. The normalized content of total phospholipid, phosphatidylcholine (PC), and disaturated phosphatidylcholine (DSPC) in bronchoalveolar lavage fluid, lung lamellar bodies, and lung homogenate was unchanged with age in wild-type mice but increased progressively in Prdx6-/-animals. Degradation of internalized [3H]DPPC in isolated mouse lungs after endotracheal instillation of unilamellar liposomes labeled with [3H]DPPC was significantly decreased at 2 h in Prdx6-/- mice (13.6 +/- 0.3% vs. 26.8 +/-0.8% in the wild type), reflected by decreased dpm in the lysophosphatidylcholine and the unsaturated PC fractions. Incorporation of [14C]palmitate into DSPC at 24 h after intravenous injection was decreased by 73% in lamellar bodies and by 54% in alveolar lavage surfactant in Prdx6-/-mice, whereas incorporation of [3H]choline was decreased only slightly. Phospholipid metabolism in Prdx6-/-lungs was similar to that in wild-type lungs treated with MJ33, an inhibitor of aiPLA2 activity. These results confirm an important role for Prdx6 in lung surfactant DPPC degradation and synthesis by the reacylation pathway."xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m400499-jlr200"xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/author | "Dodia C."xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/author | "Feinstein S.I."xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/author | "Fisher A.B."xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/author | "Ho Y.S."xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/pages | "1248-1256"xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/title | "Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2."xsd:string |
| http://purl.uniprot.org/citations/15772425 | http://purl.uniprot.org/core/volume | "46"xsd:string |
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