| http://purl.uniprot.org/citations/15774758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15774758 | http://www.w3.org/2000/01/rdf-schema#comment | "Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. To study the role of collagen VII in these cancers, we examined Ras-driven tumorigenesis in RDEB keratinocytes. Cells devoid of collagen VII did not form tumors in mice, whereas those retaining a specific collagen VII fragment (the amino-terminal noncollagenous domain NC1) were tumorigenic. Forced NC1 expression restored tumorigenicity to collagen VII-null epidermis in a non-cell-autonomous fashion. Fibronectin-like sequences within NC1 (FNC1) promoted tumor cell invasion in a laminin 5-dependent manner and were required for tumorigenesis. Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1106209"xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Lin Q."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Garcia J."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Sakai L.Y."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Marinkovich M.P."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Khavari P.A."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Green C.L."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Veitch D.P."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/author | "Ortiz-Urda S."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/pages | "1773-1776"xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/title | "Type VII collagen is required for Ras-driven human epidermal tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/15774758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15774758 |
| http://purl.uniprot.org/citations/15774758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15774758 |
| http://purl.uniprot.org/uniprot/#_A9Z119-mappedCitation-15774758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15774758 |
| http://purl.uniprot.org/uniprot/#_B0LXL0-mappedCitation-15774758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15774758 |
| http://purl.uniprot.org/uniprot/#_Q59F16-mappedCitation-15774758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15774758 |
| http://purl.uniprot.org/uniprot/#_Q02388-mappedCitation-15774758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15774758 |
| http://purl.uniprot.org/uniprot/Q02388 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15774758 |