| http://purl.uniprot.org/citations/15775988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15775988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15775988 | http://www.w3.org/2000/01/rdf-schema#comment | "C/EBP homologous protein (CHOP) is a stress-inducible nuclear protein that is crucial for the development of programmed cell death and regeneration; however, the regulation of its function has not been well characterized. Slbo, a Drosophila homolog of C/EBP (CCAAT/enhancer binding protein), was shown to be unstabilized by tribbles. Here, we identified TRB3 as a tribbles ortholog in humans, which associated with CHOP to suppress the CHOP-dependent transactivation. TRB3 is induced by various forms endoplasmic reticulum (ER) stress later than CHOP. Tunicamycin treatment enhanced the TRB3 promoter activity, while dominant-negative forms of CHOP suppressed the tunicamycin-induced activation. In addition, the tunicamycin response region in the TRB3 promoter contains amino-acid response elements overlapping the CHOP-binding site, and CHOP and ATF4 cooperated to activate this promoter activity. Knockdown of endogenous ATF4 or CHOP expression dramatically repressed tunicamycin-induced TRB3 induction. Furthermore, knockdown of TRB3 expression decreased ER stress-dependent cell death. These results indicate that TRB3 is a novel target of CHOP/ATF4 and downregulates its own induction by repression of CHOP/ATF4 functions, and that it is involved in CHOP-dependent cell death during ER stress."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600596"xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600596"xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Hattori T."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Hattori T."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Ohoka N."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Ohoka N."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Onozaki K."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Onozaki K."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Yoshii S."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/author | "Yoshii S."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/pages | "1243-1255"xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/pages | "1243-1255"xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/title | "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/title | "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15775988 | http://purl.uniprot.org/core/volume | "24"xsd:string |