| http://purl.uniprot.org/citations/15777793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15777793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15777793 | http://www.w3.org/2000/01/rdf-schema#comment | "Teneurin-1 is a type II transmembrane protein expressed in neurons of the developing and adult central nervous system. To investigate the intracellular signaling of teneurin-1, we searched for proteins interacting with its intracellular domain. One of the proteins identified is the c-Cbl-associated protein CAP/ponsin, an adaptor protein containing SH3 domains. This interaction results on one hand in the recruitment of the soluble intracellular domain of teneurin-1 to the cell membrane enriched in CAP/ponsin. On the other hand, it leads to the translocation of CAP/ponsin to the nucleus, the major site of accumulation of the intracellular domain of teneurin-1. The second interacting protein identified is the methyl-CpG binding protein MBD1. In the nucleus, the intracellular domain of teneurin-1 colocalizes with this transcriptional repressor in foci associated with the nuclear matrix. We propose that these interactions are part of a specific signaling pathway. Evidence for cleavage and nuclear translocation of the intracellular domain has been obtained by the detection of endogenous teneurin-1 immunoreactivity in nuclear speckles in chick embryo fibroblasts. Furthermore, in the nuclear matrix fraction of these cells as well as in cells expressing a hormone-inducible full-length teneurin-1 protein, a teneurin-1 fragment of identical size could be detected as in cells transfected with the intracellular domain alone."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2004.12.020"xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2004.12.020"xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Brown-Luedi M."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Brown-Luedi M."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Nunes S.M."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Nunes S.M."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Chiquet-Ehrismann R."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Chiquet-Ehrismann R."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Ferralli J."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Ferralli J."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Minet A.D."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/author | "Minet A.D."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/pages | "122-132"xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/pages | "122-132"xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/title | "The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix."xsd:string |
| http://purl.uniprot.org/citations/15777793 | http://purl.uniprot.org/core/title | "The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix."xsd:string |