| http://purl.uniprot.org/citations/15778381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15778381 | http://www.w3.org/2000/01/rdf-schema#comment | "CD8 T cells have been shown to play an important role in the clearance and protection against fatal Ebola virus infection. In this study, we examined the mechanisms by which CD8 T cells mediate this protection. Our data demonstrate that all normal mice infected s.c. with a mouse-adapted Ebola virus survived the infection, as did 100% of mice deficient in Fas and 90% of those deficient in IFN-gamma. In contrast, perforin-deficient mice uniformly died after s.c. challenge. Perforin-deficient mice failed to clear viral infection even though they developed normal levels of neutralizing anti-Ebola Abs and 5-to 10-fold higher levels of IFN-gamma than control mice. Using MHC class I tetramers, we have also shown that perforin-deficient mice have 2-to 4-fold higher numbers of Ebola-specific CD8s than control mice. These findings suggest that the clearance of Ebola virus is perforin-dependent and provide an additional example showing that this basic immunologic mechanism is not limited to the clearance of noncytopathic viruses."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.7.4198"xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Gupta M."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Rollin P.E."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Zaki S.R."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Greer P."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Ahmed R."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Mahanty S."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/author | "Shieh W.J."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/pages | "4198-4202"xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/title | "CD8-mediated protection against Ebola virus infection is perforin dependent."xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15778381 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15778381 |
| http://purl.uniprot.org/citations/15778381 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15778381 |
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| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-15778381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15778381 |
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