| http://purl.uniprot.org/citations/15778465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15778465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15778465 | http://www.w3.org/2000/01/rdf-schema#comment | "To comprehensively identify proteins interacting with 14-3-3 sigma in vivo, tandem affinity purification and the multidimensional protein identification technology were combined to characterize 117 proteins associated with 14-3-3 sigma in human cells. The majority of identified proteins contained one or several phosphorylatable 14-3-3-binding sites indicating a potential direct interaction with 14-3-3 sigma. 25 proteins were not previously assigned to any function and were named SIP2-26 (for 14-3-3 sigma-interacting protein). Among the 92 interactors with known function were a number of proteins previously implicated in oncogenic signaling (APC, A-RAF, B-RAF, and c-RAF) and cell cycle regulation (AJUBA, c-TAK, PTOV-1, and WEE1). The largest functional classes comprised proteins involved in the regulation of cytoskeletal dynamics, polarity, adhesion, mitogenic signaling, and motility. Accordingly ectopic 14-3-3 sigma expression prevented cellular migration in a wounding assay and enhanced mitogen-activated protein kinase signaling. The functional diversity of the identified proteins indicates that induction of 14-3-3 sigma could allow p53 to affect numerous processes in addition to the previously characterized inhibitory effect on G2/M progression. The data suggest that the cancer-specific loss of 14-3-3 sigma expression by epigenetic silencing or p53 mutations contributes to cancer formation by multiple routes."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m500021-mcp200"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m500021-mcp200"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Hermeking H."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Hermeking H."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Muster N."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Muster N."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Benzinger A."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Benzinger A."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Koch H.B."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/author | "Koch H.B."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/name | "Mol. Cell. Proteomics"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/name | "Mol. Cell. Proteomics"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/pages | "785-795"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/pages | "785-795"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/title | "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/title | "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer."xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/15778465 | http://purl.uniprot.org/core/volume | "4"xsd:string |