| http://purl.uniprot.org/citations/15778496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15778496 | http://www.w3.org/2000/01/rdf-schema#comment | "Bruton's tyrosine kinase (Btk) is thought to positively regulate mast cell activation, implying a role in allergic responses. We have compared acute and late phase allergic airway reactions in mice lacking either Btk or interleukin-2-inducible T cell kinase (Itk), another Tec kinase expressed in mast cells. Btk(-/-) mice showed minor protection against allergic symptoms when challenged with allergen via the airways. In sharp contrast, both acute and late phase inflammatory allergic responses were markedly reduced in Itk(-/-) mice. Notably, airway mast cell degranulation in Itk(-/-) mice was severely impaired, despite wild-type levels of allergen-specific IgE and IgG1. The degranulation defect was confirmed in DNP-conjugated human serum albumin-challenged mice passively sensitized with anti-DNP IgE antibodies, and was also observed after direct G-protein stimulation with the mast cell secretagogue c48/80. Moreover, late phase inflammatory changes, including eosinophilia, lymphocyte infiltration, and Th2 cytokine production in the lungs, was eliminated in Itk(-/-) mice. Collectively, our data suggest a critical role of Itk in airway mast cell degranulation in vivo that together with an impaired T cell response prevents the development of both acute and late phase inflammatory allergic reactions."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2004-0348oc"xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Sideras P."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Eriksson C."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Ericsson P.O."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Erjefalt J.S."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Forssell J."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Malm-Erjefalt M."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/author | "Rydell-Tormanen K."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/pages | "511-520"xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/title | "Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses."xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/15778496 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15778496 |
| http://purl.uniprot.org/citations/15778496 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15778496 |
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