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http://purl.uniprot.org/citations/15778925http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15778925http://www.w3.org/2000/01/rdf-schema#comment"

Objective

There is a high incidence of anemia in patients with advanced prostate cancer (PC) under androgen deprivation. Pathophysiology of this anemia remains unclear. Erythropoietin (EPO) is the main growth factor inducing erythropoesis in response to hypoxia. In this study, function of the EPO-system following androgen deprivation was tested in standardized animal model.

Methods

Animals were pretreated by either orchiectomy, injection of cyproteroneacetate or flutamide. After hypoxic stimulation, EPO mRNA expression and EPO serum levels were studied.

Results

In all animals, EPO mRNA expression and EPO serum levels were increased following hypoxic stimulation. Compared to the control group, this increase was even more pronounced after androgen deprivation. None of the different forms of androgen deprivation had a negative stimulating effect on EPO expression.

Conclusion

Unexpectedly, androgen deprivation did not suppress EPO mRNA expression and EPO serum concentrations. Instead, stimulation of the EPO system was even more pronounced after androgen deprivation. A deficient EPO system does not appear to contribute to the clinically observed anemia in patients treated by androgen deprivation."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.org/dc/terms/identifier"doi:10.1055/s-2005-861172"xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/author"Kurtz A."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/author"Eckardt K.U."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/author"Grimm M.O."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/author"Effert P."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/author"Voegeli T.A."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/name"Horm Metab Res"xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/pages"89-93"xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/title"Anemia under androgen deprivation: influence of flutamide, cyproteroneacetate and orchiectomy on the erythropoietin system."xsd:string
http://purl.uniprot.org/citations/15778925http://purl.uniprot.org/core/volume"37"xsd:string
http://purl.uniprot.org/citations/15778925http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15778925
http://purl.uniprot.org/citations/15778925http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15778925
http://purl.uniprot.org/uniprot/P29676#attribution-86EA83A7FAC1AF67E6594EBC4FFBF5BEhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/15778925
http://purl.uniprot.org/uniprot/#_P29676-mappedCitation-15778925http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15778925
http://purl.uniprot.org/uniprot/P29676http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15778925