| http://purl.uniprot.org/citations/15781453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15781453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15781453 | http://www.w3.org/2000/01/rdf-schema#comment | "The human hypoxia-inducible transcription factor HIF-1 is a critical regulator of cellular and systemic responses to low oxygen levels. When oxygen levels are high, the HIF-1alpha subunit is hydroxylated and is targeted for degradation by the von Hippel-Lindau tumor suppressor protein (VHL). This regulatory pathway is evolutionarily conserved, and the Caenorhabditis elegans hif-1 and vhl-1 genes encode homologs of the HIF-1alpha subunit and VHL. To understand and describe more fully the molecular basis for hypoxia response in this important genetic model system, we compared hypoxia-induced changes in mRNA expression in wild-type, hif-1-deficient, and vhl-1-deficient C. elegans using whole genome microarrays. These studies identified 110 hypoxia-regulated gene expression changes, 63 of which require hif-1 function. Mutation of vhl-1 abrogates most hif-1-dependent changes in mRNA expression. Genes regulated by C. elegans hif-1 have predicted functions in signal transduction, metabolism, transport, and extracellular matrix remodeling. We examined the in vivo requirement for 16 HIF-1 target genes and discovered that the phy-2 prolyl 4-hydroxylase alpha subunit is critical for survival in hypoxic conditions. Some HIF-1 target genes negatively regulate formation of stress-resistant dauer larvae. The microarray data presented herein also provide clear evidence for an HIF-1-independent pathway for hypoxia response, and this pathway regulates the expression of multiple heat shock proteins and several transcription factors."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m501894200"xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m501894200"xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Nettleton D."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Nettleton D."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Shen C."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Shen C."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Powell-Coffman J.A."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Powell-Coffman J.A."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Jiang M."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/author | "Jiang M."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/pages | "20580-20588"xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/pages | "20580-20588"xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/title | "Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/title | "Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15781453 | http://purl.uniprot.org/core/volume | "280"xsd:string |