http://purl.uniprot.org/citations/15788564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15788564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15788564 | http://www.w3.org/2000/01/rdf-schema#comment | "Activating transcription factor (ATF)-2 is a member of the ATF/cAMP response element-binding protein family of transcription factors, and its trans-activating capacity is enhanced by stress-activated protein kinases such as c-Jun NH(2)-terminal kinase (JNK) and p38. However, little is known about the in vivo roles played by ATF-2. Here, we identified the Drosophila homologue of ATF-2 (dATF-2) consisting of 381 amino acids. In response to UV irradiation and osmotic stress, Drosophila p38 (dp38), but not JNK, phosphorylates dATF-2 and enhances dATF-2-dependent transcription. Consistent with this, injection of dATF-2 double-stranded RNA (dsRNA) into embryos did not induce the dorsal closure defects that are commonly observed in the Drosophila JNK mutant. Furthermore, expression of the dominant-negative dp38 enhanced the aberrant wing phenotype caused by expression of a dominant-negative dATF-2. Similar genetic interactions between dATF-2 and the dMEKK1-dp38 signaling pathway also were observed in the osmotic stress-induced lethality of embryos. Loss of dATF-2 in Drosophila S2 cells by using dsRNA abrogated the induction of 40% of the osmotic stress-induced genes, including multiple immune response-related genes. This indicates that dATF-2 is a major transcriptional factor in stress-induced transcription. Thus, dATF-2 is critical for the p38-mediated stress response."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.E04-11-1008"xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e04-11-1008"xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Okamura T."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Okamura T."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Sano Y."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Sano Y."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Nagao T."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Nagao T."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Akimaru H."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/author | "Akimaru H."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/pages | "2934-2946"xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/pages | "2934-2946"xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/title | "Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase."xsd:string |
http://purl.uniprot.org/citations/15788564 | http://purl.uniprot.org/core/title | "Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase."xsd:string |