| http://purl.uniprot.org/citations/15789339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15789339 | http://www.w3.org/2000/01/rdf-schema#comment | "The CX3C chemokine fractalkine (CX3CL1) exists as both a membrane-bound form promoting firm cell-cell adhesion and a soluble form chemoattracting leukocytes expressing its receptor CX3CR1. When adenoviral vector expressing mouse fractalkine (AdFKN) was transduced to the tumor cells, fractalkine was expressed as both membrane-bound form on the tumor cells and soluble form in the supernatant in vitro. Intratumoral injection of AdFKN (1 x 10(9)PFU/tumor) into C26 and B16F10 tumors resulted in marked reduction of tumor growth compared to control (C26: 86.5%, p<0.001; B16F10: 85.5%, p<0.001). Histological examination of tumor tissues revealed abundant infiltration of NK cells, dendritic cells, and CD8(+) T lymphocytes 3 and/or 6 days after treatment with AdFKN. Splenocytes from mice treated by AdFKN developed tumor-specific cytotoxic T cells, and thereby protected from rechallenging with parental tumor cells. Antitumor effects by AdFKN were completely abrogated in both NK cell-depleted mice and CD8(-/-) mice, and partially blocked in CD4(-/-) mice. These data indicated that fractalkine mediates antitumor effects by both NK cell-dependent and T cell-dependent mechanisms. This study suggests that fractalkine can be a suitable candidate for immunogene therapy of cancer because fractalkine induces both innate and adaptive immunity."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200526042"xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Hagiwara K."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Kikuchi T."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Ohkouchi S."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Honjo T."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Nukiwa T."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Xin H."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Saijo Y."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Huqun"xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/author | "Andarini S."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/pages | "1371-1380"xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/title | "Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells."xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/15789339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15789339 |
| http://purl.uniprot.org/citations/15789339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15789339 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-15789339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15789339 |
| http://purl.uniprot.org/uniprot/#_P06332-mappedCitation-15789339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15789339 |
| http://purl.uniprot.org/uniprot/#_P01731-mappedCitation-15789339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15789339 |
| http://purl.uniprot.org/uniprot/#_O55054-mappedCitation-15789339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15789339 |
| http://purl.uniprot.org/uniprot/#_Q8CAX3-mappedCitation-15789339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15789339 |