| http://purl.uniprot.org/citations/15790596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15790596 | http://www.w3.org/2000/01/rdf-schema#comment | "In the dominant mouse mutant Odd Sex, XXOds/+ mice develop as phenotypic, sterile males due to male-pattern expression of Sox9 in XXOds/+ embryonic gonads. To test whether SOX9 was sufficient to generate a fully fertile male in the absence of Sry, we constructed an XY(Sry(-))Ods/+ male mouse, in which the male phenotype is controlled autosomally by the Ods mutation. Mice were initially fertile, but progressively lost fertility until 5-6 months when they were sterile with very few germ cells in the testis. XY(Sry-)Ods/+ males also failed to establish the correct male-specific pattern of vascularization at the time of sex determination, which could be correlated to an inability of XY(Sry-),Ods/+ males to fully down-regulate Wnt4 expression in the embryonic gonad. Increasing the amount of SOX9 by producing homozygous XY(Sry-)Ods/Ods males was able to completely rescue the phenotype and restore correct vascular patterning and long-term fertility. These data indicate that activation of SOX9 in the gonad is sufficient to trigger all the downstream events needed for the development of a fully fertile male and provide evidence that Sox9 may down-regulate Wnt4 expression in the gonad."xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddi133"xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/author | "Bishop C.E."xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/pages | "1221-1229"xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/title | "Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry."xsd:string |
| http://purl.uniprot.org/citations/15790596 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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| http://purl.uniprot.org/uniprot/#_C7B5P1-mappedCitation-15790596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15790596 |
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| http://purl.uniprot.org/uniprot/#_C7B5P6-mappedCitation-15790596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15790596 |