| http://purl.uniprot.org/citations/15791247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15791247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15791247 | http://www.w3.org/2000/01/rdf-schema#comment | "A key challenge of functional genomics today is to generate well-annotated data sets that can be interpreted across different platforms and technologies. Large-scale functional genomics data often fail to connect to standard experimental approaches of gene characterization in individual laboratories. Furthermore, a lack of universal annotation standards for phenotypic data sets makes it difficult to compare different screening approaches. Here we address this problem in a screen designed to identify all genes required for the first two rounds of cell division in the Caenorhabditis elegans embryo. We used RNA-mediated interference to target 98% of all genes predicted in the C. elegans genome in combination with differential interference contrast time-lapse microscopy. Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03353"xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03353"xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Coulson A."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Coulson A."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Jones S.J."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Jones S.J."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Hyman A.A."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Jones M."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Jones M."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Walsh A."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Walsh A."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Khan M."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Khan M."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Neumann B."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Neumann B."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Gonczy P."xsd:string |
| http://purl.uniprot.org/citations/15791247 | http://purl.uniprot.org/core/author | "Gonczy P."xsd:string |