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| http://purl.uniprot.org/citations/15791270 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila immune system is able to discriminate between classes of bacteria. Detection of Gram-positive bacteria involves a complex of two pattern recognition receptors: peptidoglycan recognition protein SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1). These activate the Toll signalling pathway. To define the cell wall components sensed by the host, we used highly purified peptidoglycan fragments of two principal Gram-positive bacterial pathogens Staphylococcus aureus and Streptococcus pneumoniae. We report that in both peptidoglycans, the minimal structure needed to activate the Toll pathway is a muropeptide dimer and that the free reducing end of the N-acetyl muramic acid residues of the muropeptides is essential for activity. Monomeric muropeptides were inactive and inhibitory in combination with dimers. Finally, peptidoglycan was degraded by the haemolymph of wild-type but not GNBP1 mutant flies. We suggest a model whereby GNBP1 is involved in the hydrolysis of Gram-positive peptidoglycan producing new glycan reducing ends, which are subsequently detected by PGRP-SA."xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400371"xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/author | "Tomasz A."xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/author | "Ligoxygakis P."xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/author | "Filipe S.R."xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/pages | "327-333"xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/title | "Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway."xsd:string |
| http://purl.uniprot.org/citations/15791270 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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