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http://purl.uniprot.org/citations/15792521http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15792521http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Erythropoietin (EPO) is a pleiotropic cytokine originally identified for its role in erythropoiesis. Recent studies have demonstrated that EPO and its receptor (EPO-R) are expressed in the central nervous system, where EPO exerts neuroprotective functions. Because the expression of the EPO and EPO-R network is poorly investigated in the central nervous system, the aim of the present study was to investigate whether the resident EPO and EPO-R network is activated in the injured nervous system.

Methods

A well-standardized model of compressive spinal cord injury in rats was used. EPO and EPO-R expression was determined by immunohistochemical analysis at 8 hours and at 2, 8, and 14 days in the spinal cord of injured and noninjured rats.

Results

In noninjured spinal cord, weak immunohistochemical expression of EPO and EPO-R was observed in neuronal and glial cells as well as in endothelial and ependymal cells. In injured rats, a marked increase of expression of EPO and EPO-R was observed in neurons, vascular endothelium, and glial cells at 8 hours after injury, peaking at 8 days, after which it gradually decreased. Two weeks after injury, EPO immunoreactivity was scarcely detected in neurons, whereas glial cells and vascular endothelium expressed strong EPO-R immunoreactivity.

Conclusion

These observations suggest that the local EPO and EPO-R system is markedly engaged in the early stages after nervous tissue injury. The reduction in EPO immunoexpression and the increase in EPO-R staining strongly support the possible usefulness of a therapeutic approach based on exogenous EPO administration."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.org/dc/terms/identifier"doi:10.1227/01.neu.0000156493.00904.7e"xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Morabito A."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Passalacqua M."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Grasso G."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Brines M.L."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Tomasello F."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Buemi M."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Sfacteria A."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/author"Macri B."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/name"Neurosurgery"xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/pages"821-827"xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/title"Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin."xsd:string
http://purl.uniprot.org/citations/15792521http://purl.uniprot.org/core/volume"56"xsd:string
http://purl.uniprot.org/citations/15792521http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15792521
http://purl.uniprot.org/citations/15792521http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15792521
http://purl.uniprot.org/uniprot/#_A0A8I6GCI9-mappedCitation-15792521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15792521
http://purl.uniprot.org/uniprot/#_O35545-mappedCitation-15792521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15792521
http://purl.uniprot.org/uniprot/#_P29676-mappedCitation-15792521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15792521
http://purl.uniprot.org/uniprot/#_Q07303-mappedCitation-15792521http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15792521
http://purl.uniprot.org/uniprot/O35545http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15792521
http://purl.uniprot.org/uniprot/Q07303http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15792521
http://purl.uniprot.org/uniprot/P29676http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15792521
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