| http://purl.uniprot.org/citations/15792957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15792957 | http://www.w3.org/2000/01/rdf-schema#comment | "Renin gene expression is subject to complex developmental and tissue-specific regulation. A comparison of the promoter sequences of the human, rat, and mouse renin genes has revealed a highly conserved sequence homologous to the DNA recognition sequence for CBF1 (CSL/RBP-Jkappa/Su(H)/LAG1/RBPSUH). Electrophoretic mobility shift assays document that As4.1 cell nuclear protein complex binding to the putative rat renin CBF1-binding site (-175 to -168 bp) contains CBF1. Transient transfection analyses in COS-7 cells further document that a CBF1-VP16 fusion protein and the intracellular domain of Notch1 robustly activate a promoter containing multiple copies of the rat renin CBF1-binding site. An Ets-binding site (-143 to -138 bp) has also been identified in the rat renin promoter by sequence comparisons and electrophoretic mobility shift assays. Transcription factor Ets-1 is capable of activating the rat renin promoter through the Ets-binding site. Mutation of the CBF-binding site significantly increases transcriptional activity of the rat renin promoter in Calu-6 and COS-7 cells but not in As4.1 cells, whereas mutation of the Ets-binding site reduces promoter activity of the rat renin gene in all three cell lines. Finally, we show that the intracellular domain of Notch1, Ets-1, and HOXD10.PBX1b.PREP1 activate the rat renin promoter cooperatively in COS-7 cells. These results strongly suggest that the renin gene is a downstream target of the Notch signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m414618200"xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/author | "Pan L."xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/author | "Jones C.A."xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/author | "Gross K.W."xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/author | "Glenn S.T."xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/pages | "20860-20866"xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/title | "Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch."xsd:string |
| http://purl.uniprot.org/citations/15792957 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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