Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/15796164http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15796164http://www.w3.org/2000/01/rdf-schema#comment"

Background

4-[3,5-Bis (trimethylsilyl) benzamido] benzoic acid (TAC-101) is a novel retinobenzoic acid derivative, which has a specific binding affinity to the retinoic acid receptors (RAR)-alpha and -beta. Apoptotic induction by TAC-101 was investigated using a rat hepatic metastatic model of rat RCN-9 colon cancer cells in vivo and FACScan analysis with the DLD-1 human colon cancer cell line in vitro.

Materials and methods

Hepatic metastatic tumors were induced using intra-portal injection of RCN-9 cells into F344 rats in vivo. TAC-101 (8 mg/kg) was orally administered for 5 consecutive days a week for 4 weeks. Subsequently, hepatic tumors were counted after laparotomy. Apoptotic index (A.I.) in the hepatic tumors was evaluated using immunohistochemistry for single-stranded DNA. The proliferative index (P.I.), Fas and Fas ligand were also immunohistochemically evaluated. Moreover, evaluation of apoptosis by TAC-101 in vitro using FACScan analysis was performed in the DLD-1 human colon cancer cell line.

Results

Oral administration of TAC-101 resulted in a significant inhibition of hepatic metastasis without weight loss of the rats. TAC-101 significantly decreased P. I. but increased A. I. in the hepatic metastatic tumors. TAC-101 did not affect the expression of Fas ligand, but obviously increased the expression of Fas in the metastatic tumors. Moreover, TAC-101 induced early apoptosis in DLD-1 cells in a time-dependent manner in vitro.

Conclusion

These findings suggest that TAC-101 inhibits hepatic metastasis of colon cancer and induces apoptosis partially through enhanced Fas expression."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Inoue Y."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Kohno K."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Itoh H."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Hirata K."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Minagawa N."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Nakayama Y."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Nagata N."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Sako T."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Onitsuka K."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Shibao K."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Katsuki T."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Ohie S."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/author"Tsurudome Y."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/name"In Vivo"xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/pages"125-132"xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/title"4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induces apoptosis in colon cancer partially through the induction of Fas expression."xsd:string
http://purl.uniprot.org/citations/15796164http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/15796164http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15796164
http://purl.uniprot.org/citations/15796164http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15796164
http://purl.uniprot.org/uniprot/#_A0A8I6ALF0-mappedCitation-15796164http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15796164
http://purl.uniprot.org/uniprot/#_A0A8I6G9W1-mappedCitation-15796164http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15796164
http://purl.uniprot.org/uniprot/#_A0A8I5ZN15-mappedCitation-15796164http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15796164
▶