| http://purl.uniprot.org/citations/15797961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15797961 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuropeptides B and W (NPB and NPW) are regulatory peptides that act via two subtypes of G protein-coupled receptors, named GPR7 and GPR8. RT-PCR demonstrated the expression of these receptors in both zona glomerulosa and zona fasciculata-reticularis (ZF/R) cells of the human adrenal cortex. NPB and NPW did not affect aldosterone secretion from dispersed zona glomerulosa cells but enhanced cortisol production from ZF/R cells, NPB being more effective than NPW. NPB evoked sizable cAMP and inositol triphosphate responses from ZF/R cells, which were abrogated by the adenylate cyclase inhibitor SQ-22536 and the phospholipase C inhibitor U-73122, respectively. Cortisol response to NPB was lowered by either SQ-22536 and the protein kinase (PK) A inhibitor H-89 or U-73122 and the PKC inhibitor calphostin-C and abolished by the simultaneous exposure to H-89 and calphostin-C. NPW elicited only a rise in cAMP production from dispersed ZF/R cells, and its cortisol response was suppressed by both SQ-22536 and H-89. PreproNPB and preproNPW mRNAs were detected in human adrenal cortexes. We conclude that: 1) NPB and NPW exert a secretagogue action on human ZF/R cells, probably acting in an autocrine-paracrine manner; and 2) the effect of NPB is mediated by both the adenylate cyclase/PKA and the phospholipase C/PKC cascades, whereas that of NPW involves only the activation of the former signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2004-2132"xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/author | "Nussdorfer G.G."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/author | "Malendowicz L.K."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/author | "Ziolkowska A."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/author | "Rossi G.P."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/author | "Rebuffat P."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/author | "Mazzocchi G."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/pages | "3466-3471"xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/title | "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades."xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/15797961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15797961 |
| http://purl.uniprot.org/citations/15797961 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15797961 |
| http://purl.uniprot.org/uniprot/#_H9NIL7-mappedCitation-15797961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/#_P48145-mappedCitation-15797961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/#_P48146-mappedCitation-15797961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/#_Q6NWQ5-mappedCitation-15797961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/Q6NWQ5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/P48145 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/P48146 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15797961 |
| http://purl.uniprot.org/uniprot/H9NIL7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15797961 |