| http://purl.uniprot.org/citations/15798186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15798186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15798186 | http://www.w3.org/2000/01/rdf-schema#comment | "The SR family proteins and SR-related polypeptides are important regulators of pre-mRNA splicing. A novel SR-related protein of an apparent molecular mass of 53 kDa was isolated in a gene trap screen that identifies proteins which localize to the nuclear speckles. This novel protein possesses an arginine- and serine-rich domain and was termed SRrp53 (for SR-related protein of 53 kDa). In support for a role of this novel RS-containing protein in pre-mRNA splicing, we identified the mouse ortholog of the Saccharomyces cerevisiae U1 snRNP-specific protein Luc7p and the U2AF65-related factor HCC1 as interacting proteins. In addition, SRrp53 is able to interact with some members of the SR family of proteins and with U2AF35 in a yeast two-hybrid system and in cell extracts. We show that in HeLa nuclear extracts immunodepleted of SRrp53, the second step of pre-mRNA splicing is blocked, and recombinant SRrp53 is able to restore splicing activity. SRrp53 also regulates alternative splicing in a concentration-dependent manner. Taken together, these results suggest that SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.8.2969-2980.2005"xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.8.2969-2980.2005"xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/author | "Newton K."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/author | "Newton K."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/author | "Caceres J.F."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/author | "Caceres J.F."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/author | "Cazalla D."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/author | "Cazalla D."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/pages | "2969-2980"xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/pages | "2969-2980"xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/title | "A novel SR-related protein is required for the second step of pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/title | "A novel SR-related protein is required for the second step of pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/15798186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15798186 |
| http://purl.uniprot.org/citations/15798186 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15798186 |
| http://purl.uniprot.org/citations/15798186 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15798186 |
| http://purl.uniprot.org/citations/15798186 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15798186 |