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| http://purl.uniprot.org/citations/15802517 | http://www.w3.org/2000/01/rdf-schema#comment | "A mutant allele (pol3-L612M) of the DNA polymerase delta gene in Saccharomyces cerevisiae that confers sensitivity to the antiviral drug phosphonoacetic acid (PAA) was constructed. We report that PAA-sensitivity tagging DNA polymerases is a useful method for selectively and reversibly inhibiting one type of DNA polymerase. Our initial studies reveal that replication by the L612M-DNA pol delta requires Rad27 flap endonuclease activity since the pol3-L612M strain is not viable in the absence of RAD27 function. The L612M-DNA pol delta also strongly depends on mismatch repair (MMR). Reduced viability is observed in the absence of any of the core MMR proteins-Msh2, Mlh1, or Pms1-and severe sensitivity to PAA is observed in the absence of the core proteins Msh6 or Exo1, but not Msh3. We propose that pol3-L612M cells need the Rad27 flap endonuclease and MMR complexes composed of Msh2/Msh6, Mlh1/Pms1, and Exo1 for correct processing of Okazaki fragments."xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.104.040295"xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/author | "Reha-Krantz L.J."xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/author | "Kanevets U."xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/pages | "569-580"xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/title | "Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/15802517 | http://purl.uniprot.org/core/volume | "170"xsd:string |
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