| http://purl.uniprot.org/citations/15804285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15804285 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor (TGF)-beta, a pleiotropic cytokine that has multiple effects on immune responses, has been shown to inhibit interleukin (IL)-4/GATA-3 expression as well as T helper 2 (Th2) differentiation. Consistent with these reports, we found that priming T cells from DO11.10 transgenic mice with antigen in the presence of TGF-beta inhibited GATA-3 expression and the development of IL-4-producing T cells. Unexpectedly, the inhibition of Th2 development was accompanied by a substantial increase in the number of interferon-gamma (IFN-gamma)-producing cells. T cells primed with TGF-beta secreted IFN-gamma in response to both T-cell receptor ligation and IL-12/IL-18 stimulation, and expressed high levels of T-bet and low levels of GATA-3. The TGF-beta-mediated enhancement of T helper 1 (Th1) priming was independent of IL-12 and signal transducer and activator of transcription (STAT)-4, but required endogenous IFN-gamma. TGF-beta-mediated enhancement of the IFN-gamma-dependent, IL-12-independent pathway of Th1 priming was mediated primarily by the inhibition of IL-4 produced by memory/activated T cells in the unfractionated CD4+ responder population. Nevertheless, TGF-beta did not inhibit this pathway of Th1 differentiation when purified naive CD4+ T cells were used as responders. These data have important implications for strategies being considered for the use of TGF-beta-producing T cells for the treatment of autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2005.02115.x"xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/author | "Shevach E.M."xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/author | "Smeltz R.B."xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/pages | "484-492"xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/title | "Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/15804285 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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