| http://purl.uniprot.org/citations/15805299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15805299 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-4 exhibits antitumor activity in rodent experimental gliomas, which is likely mediated by the actions of IL-4 on a variety of immune cells present in and around the tumor masses. Here, we show that IL-4, which activates Stat6 in normal human astrocytes and in a variety of other cells, induces an aberrant activation of Stat3 in glioblastoma multiforme (GBM) cells but not in normal human astrocytes. Previously, we have shown that autocrine IL-6 signaling induces a persistent activation of Stat3. Now, we show that Stat3 is further activated by IL-4 stimulation of GBM cells. Expression of IL-13Ralpha2, a decoy receptor for IL-13 that partly blocks IL-4-mediated activation of Stat6 in GBM cells, up-regulates the activation of Stat3 as shown by a small interfering RNA-mediated inhibition of IL-13Ralpha2 expression. In addition, transient expression of the IL-13Ralpha2 transgene in 293T cells increases the IL-4-mediated activation of Stat3 and subsequent expression of Stat3-targeted gene. Coimmunoprecipitation results reveal that IL-13Ralpha2-mediated activation of Stat3 does not require a direct physical interaction between Stat3 and IL-13Ralpha2. Chromatin immunoprecipitation assay employing anti-Stat3 antibody confirms the in vivo binding of activated Stat3 to the promoters of genes that encode antiapoptotic proteins Bcl-2, Bcl-x(L), and Mcl-1. IL-4 significantly up-regulates of the steady-state levels of Bcl-2, Bcl-x(L), and Mcl-1 in GBM cells. These results indicate that IL-4/IL-13 receptor-mediated Stat3 signaling may contribute to the pathogenesis of GBM cells by modulating the expression of the Bcl-2 family of antiapoptotic proteins."xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-04-3592"xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/author | "Haque S.J."xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/author | "Rahaman S.O."xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/author | "Vogelbaum M.A."xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/pages | "2956-2963"xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/title | "Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2."xsd:string |
| http://purl.uniprot.org/citations/15805299 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P52333-mappedCitation-15805299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15805299 |
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