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http://purl.uniprot.org/citations/15807454http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15807454http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To study possible immunogenetic HLA markers of chronic viral hepatitides.

Material and methods

Using the reaction of complement-dependent cytotoxicity by Terasaki, we analysed distribution of leukocytic HLA antigens (loci A, B and C) in 179 patients with chronic viral hepatitides B, C and D in Russians and Kazakhs living in the Astrakhan Region.

Results

In the Russian population we discovered a significant positive association of CVHB with HLA-B18, HLA-B35, HLA-B40, HLA-Cw3 antigens, and negative one--with HLA-A2. In Kazakhs with CVHB there was a positive association with HLA-A3, HLA-B18 and negative one--with HLA-A11. Alleles HLA-A10, HLA-B35, HLA-B40 and HLA-Cw3 mark CVHC in Russians. HLA-Cw4 specificity acts as protector in development of chronic HCV-infection. A correlation was found between carriage of some specificities and haplotypes of HLA and activity of chronic HBV and HCV infection. A high risk of chronic delta infection in Russians is associated with HLA-B8 and HLA-B35, in Kazakhs--with HLA-B35 and HLA-D40. There are significant associations between CVHB, CVHC, chronic delta infection and some HLA haplotypes.

Conclusion

A universal role of HLA-B35 specificity in development of CVH irrespective of hepatotropic virus and patients' nationality is shown."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/author"Alekseev L.P."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/author"Levitan B.N."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/author"Popov E.A."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/author"Pronina O.A."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/author"Suchkov S.V."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/name"Ter Arkh"xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/pages"54-59"xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/title"[Immunogenetic HLA markers of chronic viral hepatitis]."xsd:string
http://purl.uniprot.org/citations/15807454http://purl.uniprot.org/core/volume"77"xsd:string
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