| http://purl.uniprot.org/citations/15809326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15809326 | http://www.w3.org/2000/01/rdf-schema#comment | "Group 2 major mite allergens Der f 2 and Der p 2 are classified into the recently identified group of MD-2-related lipid-recognition (ML) proteins, but the ligands and biological functions of these allergens are unknown. We have obtained a high-quality NMR structure for Der f 2, and found that it is more similar to the crystal structure of NPC2, a distant homologue, than to that of Der p 2, in terms of the separation and angle between the two major beta-sheets. This made us propose that ML proteins undergo clamshell-like motions that change the sizes of ligand-binding spaces inside their immunoglobulin-fold beta-sandwich to accommodate lipid molecules. This type of motion in lipopolysaccaride recognition of MD-2 is suggested to be likely as well by structural models. We also report the applicability of NMR differential exchange broadening experiments for complexes of intact monoclonal antibodies and antigens; using this technique, we have detected the conformational epitopes for monoclonal antibodies 15E11 and 13A4 as two separate surface patches."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvi039"xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Inagaki F."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Hatanaka H."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Ogura K."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Ichikawa S."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Yuuki T."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/author | "Okumura Y."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/pages | "255-263"xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/title | "NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members."xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/15809326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15809326 |
| http://purl.uniprot.org/citations/15809326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15809326 |
| http://purl.uniprot.org/uniprot/#_Q00855-mappedCitation-15809326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15809326 |
| http://purl.uniprot.org/uniprot/Q00855 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15809326 |