| http://purl.uniprot.org/citations/15811338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15811338 | http://www.w3.org/2000/01/rdf-schema#comment | "Aftiphilin was identified through a database search for proteins containing binding motifs for the gamma-ear domain of clathrin adaptor protein 1 (AP-1). Here, we demonstrate that aftiphilin is expressed predominantly in brain where it is enriched on clathrin-coated vesicles. In addition to eight gamma-ear-binding motifs, aftiphilin contains two WXXF-acidic motifs that mediate binding to the alpha-ear of clathrin adaptor protein 2 (AP-2) and three FXXFXXF/L motifs that mediate binding to the alpha- and beta2-ear. We demonstrate that aftiphilin uses these motifs for interactions with AP-1 and AP-2 and that it immunoprecipitates these APs but not AP-3 or AP-4 from brain extracts. Aftiphilin demonstrates a brefeldin A sensitive localization to the trans-Golgi network in hippocampal neurons where it co-localizes with AP-1. Aftiphilin is also found at synapses where it co-localizes with synaptophysin and AP-2. Our data suggest a role for aftiphilin in clathrin-mediated trafficking in neurons."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.03.008"xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/author | "McPherson P.S."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/author | "Ritter B."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/author | "Burman J.L."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/author | "Wasiak S."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/author | "de Heuvel E."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/pages | "2177-2184"xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/title | "Aftiphilin is a component of the clathrin machinery in neurons."xsd:string |
| http://purl.uniprot.org/citations/15811338 | http://purl.uniprot.org/core/volume | "579"xsd:string |
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