| http://purl.uniprot.org/citations/15811952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15811952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15811952 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor in lung cancer-1 (TSLC1) gene is frequently silenced in human lung carcinomas, and its expression suppresses tumorigenesis in nude mice. TSLC1 encodes a cell-surface protein called Necl-2 that belongs to the Nectin and Nectin-like (Necl) family of molecules. Necl-2 mediates epithelial cell junctions by homotypic contacts and/or heterotypic interactions with other Nectins and Necls. Thus, it inhibits tumorigenesis by ensuring that epithelial cells grow in organized layers. Here, we demonstrate that natural killer (NK) cells and CD8+ T cells recognize Necl-2 through a receptor known as class I-restricted T-cell-associated molecule (CRTAM), which is expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and interferon gamma (IFN-gamma) secretion of CD8+ T cells in vitro as well as NK cell-mediated rejection of tumors expressing Necl-2 in vivo. These results provide evidence for an additional mechanism of tumor suppression mediated by TSLC1 that involves cytotoxic lymphocytes. Furthermore, they reveal Necl-2 as one of the molecular targets that allows the immunosurveillance network to distinguish tumor cells from normal cells."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-02-0817"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-02-0817"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Barchet W."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Barchet W."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Boles K.S."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Boles K.S."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Diacovo T."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/author | "Diacovo T."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/pages | "779-786"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/pages | "779-786"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/title | "The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/title | "The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/15811952 | http://purl.uniprot.org/core/volume | "106"xsd:string |