| http://purl.uniprot.org/citations/15814693 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15814693 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)/herpes simplex virus entry mediator (HVEM) and LIGHT/lymphotoxin beta receptor (LT beta R) interactions decreases mortality in MHC class I and II disparate graft-vs-host disease (GVHD). The present studies assessed the effects of these interactions on the generation of CD4+ T cell alloresponses in MHC class II-disparate MLC and GVHD. An inhibitor protein of LIGHT and LT alpha beta2 (LT beta R-Ig) and an inhibitor protein of LIGHT (HVEM-Ig) caused similar decreases in alloresponses of control B6 or B6.129S1-IL12rb2(tm1Jm) (B6.IL12R-/-) spleen cells (SpC) in a MHC class II-disparate MLC. GVHD-induced wasting disease in MHC class II-disparate recipients of B6 CD4+ SpC who received either the LT beta R-Ig-encoding adenovirus (LT beta R-Ig Adv; 13.1 +/-10.9%; n = 10; p = 0.0004) or the HVEM-Ig-encoding adenovirus (HVEM-Ig Adv; 16.4 +/-9.9%; n = 13; p = 0.0008) was significantly reduced compared with that in recipients of a control adenovirus (30.4 +/-8.8%; n = 13). Furthermore, gut GVHD histologic scores of recipients of B6 CD4+ SpC who received the LT beta R-Ig Adv (0.8 +/-0.8; n = 5; p = 0.0007) or the HVEM-Ig Adv (1.4 +/-0.5; n = 5; p = 0.008) were reduced compared with scores of recipients of a control adenovirus (2.5 +/-0.75; n = 11). In the intestine, both LT beta R-Ig Adv and HVEM-Ig Adv decreased CD4+ T cells (0.35 +/- 0.4 x 10(6) (n = 6) vs 0.36 +/-0.02 x 10(6) (n = 9); p = 0.03 and p = 0.007) compared with control adenovirus (0.86 +/-0.42 x 10(6); n = 9). LIGHT is critical for optimal CD4+ T cell alloresponses in MHC class II-disparate MLC and GVHD."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.8.4688"xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/author | "Brown G.R."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/author | "Luck C."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/author | "Lee E.L."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/author | "El-Hayek J."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/author | "Kintner K."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/pages | "4688-4695"xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/title | "IL-12-independent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease."xsd:string |
| http://purl.uniprot.org/citations/15814693 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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