| http://purl.uniprot.org/citations/15814704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15814704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15814704 | http://www.w3.org/2000/01/rdf-schema#comment | "The NK cell receptor protein 1 (NKR-P1) (CD161) molecules represent a family of type II transmembrane C-type lectin-like receptors expressed predominantly by NK cells. Despite sharing a common NK1.1 epitope, the mouse NKR-P1B and NKR-P1C receptors possess opposing functions in NK cell signaling. Engagement of NKR-P1C stimulates cytotoxicity of target cells, Ca2+ flux, phosphatidylinositol turnover, kinase activity, and cytokine production. In contrast, NKR-P1B engagement inhibits NK cell cytotoxicity. Nonetheless, it remains unclear how different signaling outcomes are mediated at the molecular level. Here, we demonstrate that both NKR-P1B and NKR-P1C associate with the tyrosine kinase, p56(lck). The interaction is mediated through the di-cysteine CxCP motif in the cytoplasmic domains of NKR-P1B/C. Disrupting this motif leads to abrogation of both stimulatory and inhibitory NKR-P1 signals. In addition, mutation of the consensus ITIM (LxYxxL) in NKR-P1B abolishes both its Src homology 2-containing protein tyrosine phosphatase-1 recruitment and inhibitory function. Strikingly, engagement of NKR-P1C on NK cells obtained from Lck-deficient mice failed to induce NK cytotoxicity. These results reveal a role for Lck in the initiation of NKR-P1 signals, and demonstrate a requirement for the ITIM in NKR-P1-mediated inhibition."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.8.4789"xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.8.4789"xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Nakagawa R."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Nakagawa R."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Filipp D."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Filipp D."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Carlyle J.R."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Ljutic B."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Ljutic B."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Julius M."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Julius M."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Zuniga-Pfluecker J.C."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/author | "Zuniga-Pfluecker J.C."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/pages | "4789-4796"xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/pages | "4789-4796"xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/title | "Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors."xsd:string |
| http://purl.uniprot.org/citations/15814704 | http://purl.uniprot.org/core/title | "Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors."xsd:string |