| http://purl.uniprot.org/citations/15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15814705 | http://www.w3.org/2000/01/rdf-schema#comment | "Marginal zone (MZ) B cells and peritoneal B-1 cells provide a first defense system of thymus-independent Ab responses against foreign pathogens and therefore share a number of functional properties. Recently, development of B-1a cells was shown to be controlled by the transcription factor NFATc1. We show here that mice deficient for NFATc2 and c3 display a distinct lower representation of MZ B cells, which is correlated with a reduced capturing of trinitrophenyl-Ficoll. In contrast, mature follicular B cells from NFATc2/c3-/-mice are strongly increased in number. NFATc2/c3-/-B cells exhibit a marked increase in BCR-induced intracellular Ca2+ mobilization and proliferation. However, trinitrophenyl-Ficoll-specific IgM and IgG3 responses of NFATc2/c3-deficient mice are intact, and chimeric mice reconstituted with NFATc2/3-deficient B cells show a normal number of MZ B cells and normal BCR responses. These observations suggest that the strongly elevated Th2 cytokine milieu in NFATc2/c3-deficient mice leads to a hyperactivation of mature, follicular B cells, whereas MZ B cells are less responsive to these signals."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.8.4797"xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/author | "Nitschke L."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/author | "Wirth T."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/author | "Serfling E."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/author | "Marinkovic D."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/author | "Palmetshofer A."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/author | "Samanta D.N."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/pages | "4797-4802"xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/title | "B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15814705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15814705 |
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| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |
| http://purl.uniprot.org/uniprot/#_D3YU28-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |
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| http://purl.uniprot.org/uniprot/#_B5B2P8-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |
| http://purl.uniprot.org/uniprot/#_B5B2Q2-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |
| http://purl.uniprot.org/uniprot/#_B5B2Q4-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |
| http://purl.uniprot.org/uniprot/#_B5B2Q6-mappedCitation-15814705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15814705 |