| http://purl.uniprot.org/citations/15814715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15814715 | http://www.w3.org/2000/01/rdf-schema#comment | "It is well established that tumor progression is associated with the accumulation of myeloid suppressive cells, which in mice include Gr-1+ immature myeloid cells and F4/80+ macrophages. The paradox is that with the exception of terminal stages of the disease or chemotherapy treatment, tumor-bearing mice or cancer patients do not display a profound systemic immune suppression. We therefore raised the question as to whether myeloid cell-mediated T cell suppression is controlled at a local level at the site of the tumor. We have demonstrated that after adoptive transfer to tumor-bearing recipients, Gr-1+ (immature myeloid cells) freshly isolated from spleens of tumor-bearing mice become F4/80+ tumor-associated macrophages (TAM). These TAM, but not F4/80+ macrophages or Gr-1+ cells freshly isolated from spleens of tumor-bearing or naive mice were able to inhibit T cell-mediated immune response in vitro via induction of T cell apoptosis. Arginase and NO were both responsible for the apoptotic mechanism, and were seen only in TAM, but not in freshly isolated Gr1+ cells. Using the analysis of STAT activity in combination with STAT knockout mice, we have determined that STAT1, but not STAT3 or STAT6, was responsible for TAM-suppressive activity."xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.8.4880"xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/author | "Gabrilovich D.I."xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/author | "Kusmartsev S."xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/pages | "4880-4891"xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/title | "STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion."xsd:string |
| http://purl.uniprot.org/citations/15814715 | http://purl.uniprot.org/core/volume | "174"xsd:string |
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