| http://purl.uniprot.org/citations/15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15816000 | http://www.w3.org/2000/01/rdf-schema#comment | "CD72 has been reported to regulate BCR-mediated signals both positively and negatively. SHP-1 and Grb2 bind, respectively, to ITIM1 and ITIM2 of CD72. We generated transformed B cell lines with an immature phenotype following J2 virus infection of splenocytes from CD72(-/-) and wild-type (Wt) mice. The transformed lines were infected with retroviral vectors carrying Tyr (Y) to Phe (F) substitutions in the ITIM sequences (ITIM1 mutated: Y7/F; ITIM2 mutated: Y39/F; and both ITIM mutated: Y7,39/F). Cross-linking of the BCR induced growth inhibition in transfectants expressing Wt CD72, but this response was less sensitive in transfectants with Y7,39/F. The Y7/F transfectants demonstrated the least sensitive response. We were not able to obtain transfectants with Y39/F, suggesting that CD72 associated with SHP-1, but not with Grb2, delivers a strong negative signal. Pre-ligation of CD72, which induces dephosphorylation of the molecule, partially rescued the Wt transfectants from growth inhibition, leading to a growth response profile similar to that of Y7,39/F transfectants. These results suggest that ITIM1/SHP-1 delivers a very strong negative signal that is down-modulated by signals through ITIM2/Grb2, leading to delivery of an attenuated negative signal. Thus, pre-ligation of CD72 results in the manifestation of an ostensible positive signal."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200425775"xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Baba T."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Aoyama A."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Li D.H."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Parnes J.R."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Hozumi N."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Fusaki N."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/author | "Okamura R.M."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/pages | "1634-1642"xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/title | "Dual regulation of BCR-mediated growth inhibition signaling by CD72."xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/15816000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15816000 |
| http://purl.uniprot.org/citations/15816000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15816000 |
| http://purl.uniprot.org/uniprot/#_A2AIN5-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_Q3UNJ0-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_Q99L55-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_P21855-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_Q3UZ35-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_Q3UB58-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_Q8CIX9-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |
| http://purl.uniprot.org/uniprot/#_Q8CIY0-mappedCitation-15816000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15816000 |