| http://purl.uniprot.org/citations/15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15817490 | http://www.w3.org/2000/01/rdf-schema#comment | "Second messengers generated from membrane lipids play a critical role in signaling and control diverse cellular processes. Despite being one of the most evolutionarily conserved of all the phosphoinositide-specific phospholipase C (PLC) isoforms, a family of enzymes responsible for hydrolysis of the membrane lipid phosphatidylinositol bisphosphate, the mechanism of PLC-delta1 activation is still poorly understood. Here we report a novel regulatory mechanism for PLC-delta1 activation that involves direct interaction of the small GTPase Ral and the universal calcium-signaling molecule calmodulin (CaM) with PLC-delta1. In addition, we have identified a novel IQ type CaM binding motif within the catalytic region of PLC-delta1 that is not found in other PLC isoforms. Binding of CaM at the IQ motif inhibits PLC-delta1 activity, while addition of Ral reverses the inhibition. The overexpression of various Ral mutants in cells potentiates PLC-delta1 activity. Thus, the Ral-CaM complex defines a multifaceted regulatory mechanism for PLC-delta1 activation."xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m412966200"xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/author | "Sidhu R.S."xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/author | "Bhullar R.P."xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/author | "Clough R.R."xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/pages | "21933-21941"xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/title | "Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin."xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15817490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15817490 |
| http://purl.uniprot.org/citations/15817490 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15817490 |
| http://purl.uniprot.org/uniprot/#_P11233-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_A0A384MR47-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_A8K8F9-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_B3KXR5-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_A6K9A1-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_A6K9A2-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_A6K9A3-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_B4DJ51-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_P51178-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_Q59EE9-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_P0DP23-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |
| http://purl.uniprot.org/uniprot/#_P0DP24-mappedCitation-15817490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15817490 |