| http://purl.uniprot.org/citations/15817640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15817640 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies of myoglobin (Mb) knockout (myo-/-) mice have extended our understanding of Mb's diverse functions and have demonstrated a complex array of compensatory mechanisms. The present study was aimed at detailed analysis of cardiac function and exercise endurance in myo-/-mice and at providing evidence for Mb's functional relevance. Myo-/-isolated working hearts display decreased contractility (dP/dtmax 3883+/-351 vs. 4618+/-268 mmHg/sec, myo-/-vs. WT, P<0.005). Due to a shift in sympathetic/parasympathetic tone, heart rate is reduced in conscious myo mice-/- (615+/-33 vs. 645+/-27 bpm, myo-/-vs. WT, P<0.001). Oxygen consumption (VO2) under resting conditions (3082+/-413 vs. 4452+/-552 ml x kg(-1) x h(-1), myo-/-vs. WT, P<0.001) and exercise endurance, as determined by spiroergometry, are decreased (466+/-113 vs. 585+/-153 m, myo-/- vs. WT, P<0.01). Conscious myo-/-mice evaluated by echocardiography display lowered cardiac output (0.64+/-0.06 vs. 0.75+/-0.09 ml x min(-1) x g(-1), myo-/-vs. WT, P<0.001), impaired systolic shortening (60+/-3.5 vs. 65+/-4%, myo-/-vs. WT, P<0.001) and fail to respond to beta1-stimulation. Strikingly, the latter cardiac effects of Mb deficiency can be partially attenuated by NOS inhibition. Loss of Mb results in a distinct phenotype, even under resting conditions, and the importance of oxygen supply and nitric oxide scavenging by Mb is clearly demonstrated at the conscious animal level."xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.04-2886fje"xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/author | "Schrader J."xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/author | "Godecke A."xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/author | "Flogel U."xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/author | "Merx M.W."xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/pages | "1015-1017"xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/title | "Oxygen supply and nitric oxide scavenging by myoglobin contribute to exercise endurance and cardiac function."xsd:string |
| http://purl.uniprot.org/citations/15817640 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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