| http://purl.uniprot.org/citations/15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15818404 | http://www.w3.org/2000/01/rdf-schema#comment | "Treatment of Jurkat cells with specific inhibitors of protein kinase CK2 induces apoptosis. Here we provide evidence that the anti-apoptotic effect of CK2 can be at least partially mediated by upregulation of the Akt/PKB pathway. Such a conclusion is based on the following observations: (1) inhibition of CK2 by cell treatment with two structurally unrelated CK2 inhibitors induces downregulation of Akt/PKB, as judged from decreased phosphorylation of its physiological targets, and immunoprecipitate kinase assay; (2) similar results are observed upon reduction of CK2 catalytic subunit by the RNA-interference technique; (3) Akt/PKB Ser129 is phosphorylated by CK2 in vitro and in vivo; (4) such a phosphorylation of activated Akt/PKB correlates with a further increase in catalytic activity. These data disclose an unanticipated mechanism by which constitutive phosphorylation by CK2 may be required for maximal activation of Akt/PKB."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401604"xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Pinna L.A."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Marin O."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Arrigoni G."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Ruzzene M."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Sarno S."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Di Maira G."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Salvi M."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/author | "Brustolon F."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/pages | "668-677"xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/title | "Protein kinase CK2 phosphorylates and upregulates Akt/PKB."xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15818404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15818404 |
| http://purl.uniprot.org/citations/15818404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15818404 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLE4-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLQ2-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM55-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM74-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |
| http://purl.uniprot.org/uniprot/#_D3YYP9-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |
| http://purl.uniprot.org/uniprot/#_D3YXX3-mappedCitation-15818404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15818404 |