| http://purl.uniprot.org/citations/15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15820145 | http://www.w3.org/2000/01/rdf-schema#comment | "It is known that expression of the macrophage colony-stimulating factor (M-CSF) gene is induced in articular chondrocytes upon inflammation. However, the functional role of M-CSF in cartilage has been unclear. In this study, we describe possible roles of M-CSF in the protection and maintenance of the articular cartilage based on the results of experiments using human chondrocytic cells and rat primary chondrocytes. Connective tissue growth factor (CTGF/CCN2) is known to be a potent molecule to regenerate damaged cartilage by promoting the growth and differentiation of articular chondrocytes. Here, we uncovered the fact that M-CSF induced the mRNA expression of the ctgf/ccn2 gene in those cells. Enhanced production of CTGF/CCN2 protein by M-CSF was also confirmed. Furthermore, M-CSF could autoactivate the m-csf gene, forming a positive feed-back network to amplify and prolong the observed effects. Finally, promotion of proteoglycan synthesis was observed by the addition of M-CSF. These findings taken together indicate novel roles of M-CSF in articular cartilage metabolism in collaboration with CTGF/CCN2, particularly during an inflammatory response. Such roles of M-CSF were further supported by the distribution of M-CSF producing chondrocytes in experimentally induced rat osteoarthritis cartilage in vivo."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bone.2004.10.015"xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Doi H."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Fujisawa T."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Oka M."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Eguchi T."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Kubota S."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Nakao K."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Nishida T."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/author | "Takigawa M."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/name | "Bone"xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/pages | "884-892"xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/title | "Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism."xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/15820145 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15820145 |
| http://purl.uniprot.org/citations/15820145 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15820145 |
| http://purl.uniprot.org/uniprot/#_B2RCP7-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |
| http://purl.uniprot.org/uniprot/#_B3KRV6-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |
| http://purl.uniprot.org/uniprot/#_B4DTX0-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |
| http://purl.uniprot.org/uniprot/#_B3KWK5-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |
| http://purl.uniprot.org/uniprot/#_F6MF51-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |
| http://purl.uniprot.org/uniprot/#_P09603-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |
| http://purl.uniprot.org/uniprot/#_P29279-mappedCitation-15820145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15820145 |