| http://purl.uniprot.org/citations/15821743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15821743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15821743 | http://www.w3.org/2000/01/rdf-schema#comment | "The PAS (PER-ARNT-SIM) helix-loop-helix transcription factor BMAL1 (also known as MOP3) is an essential component of the circadian pacemaker in mammals. Here we show that the retinoic acid receptor-related orphan receptor RORalpha (NR1F1) directly activates transcription of Bmal1 through two conserved RORalpha response elements that are required for cell-autonomous transcriptional oscillation of Bmal1 mRNA. Positive involvement of RORalpha in generation of the Bmal1 circadian oscillation was verified by behavioral analyses of RORalpha-deficient staggerer mice that showed aberrant locomotor activity and unstable rhythmicity. In cultured cells, loss of endogenous RORalpha protein resulted in a dampened circadian rhythm of Bmal1 transcription, further indicating that RORalpha is a functional component of the cell-autonomous core circadian clock. These results indicate that RORalpha acts to promote Bmal1 transcription, thereby maintaining a robust circadian rhythm."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb925"xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb925"xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/author | "Takumi T."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/author | "Takumi T."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/author | "Akashi M."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/author | "Akashi M."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/pages | "441-448"xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/title | "The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/title | "The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1."xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15821743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15821743 |
| http://purl.uniprot.org/citations/15821743 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15821743 |
| http://purl.uniprot.org/citations/15821743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15821743 |
| http://purl.uniprot.org/citations/15821743 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15821743 |
| http://purl.uniprot.org/uniprot/P51448 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15821743 |
| http://purl.uniprot.org/uniprot/P51448#attribution-C2E153CFE0A03E8C5E878A8937898740 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15821743 |