| http://purl.uniprot.org/citations/15823561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15823561 | http://www.w3.org/2000/01/rdf-schema#comment | "Caldesmon (CaD) is an actin-binding protein that is capable of inhibiting the actomyosin ATPase activity in vitro. CaD has a single gene that is alternatively spliced to generate the smooth muscle-specific form, h-CaD, and a shorter isoform, l-CaD, that is present only in non-muscle cells. The difference between h- and l-CaD is a highly charged repeating sequence, corresponding to a 35 nm-long single helical region that separates the N-terminal domain from the C-terminal domain of h-CaD. To test whether such an elongated h-CaD is essential for smooth muscles to function properly, we have specifically abrogated its expression in the mouse by targeting h-CaD without affecting the expression of l-CaD. After genotyping, we have obtained homozygous knockout mice that indeed lack h-CaD, but nevertheless express varying amounts of l-CaD in a tissue-dependent fashion. The contractility of smooth muscles isolated from the knockout animals is currently under investigation."xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.03.089"xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/author | "Wang C.L."xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/pages | "1132-1137"xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/title | "Specific disruption of smooth muscle caldesmon expression in mice."xsd:string |
| http://purl.uniprot.org/citations/15823561 | http://purl.uniprot.org/core/volume | "330"xsd:string |
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